The meeting will begin at 12 noon on July 12 and will conclude around 6 pm on July 13. Breakfast and lunch will be served and a poster session will take place on the afternoon of July 13. 

Afternoon of July 12

12:00 – 1:00    Welcome Lunch (Colloquium, 6th floor Ross) / Setup Posters (Blau Lobby)

1:00 – 1:15      Introduction (Blau Auditorium, Ross School of Business)

This session will lay out the charge of the meeting, which is to review the uses of 1000 Genomes and sequencing in genetic studies, but also to have a discussion about the future of community resource sequencing projects.

·  Gonçalo Abecasis (University of Michigan)

Introduction and Charge of the Meeting

1:15 – 2:45      Plenary Session I – Advances in the Analysis of Next Generation Data

Presenters will discuss advances in the analysis of next generation sequencing; presenters should discuss current challenges and data resources that might help drive further advances in at least 1-2 slides.

1:15 - 1:45 Eric Banks (Broad Institute of Harvard and MIT)

Beyond SNPs: Advances in Calling of Variants and Haplotypes

1:45 - 2:15 Hyun Min Kang (University of Michigan)

Xeroxing the Genome: Advances in Analysis of Population Sequence Data

2:15 - 2:30 Benjamin Neale (Massachusetts General Hospital)

Methods for Analysis of De Novo Mutation, with Application to Autism Trios

2:30 - 2:45 Yaniv Erlich (Whitehead Institute)

Population-scale profile of short tandem repeat variations

2:45 – 3:15      Afternoon Snack / Poster Viewing (Blau Lobby)

3:15 – 4:45      Plenary Session II – The Future Of Sequencing Data Generation and Analysis

Presenters will discuss advances in production of next generation sequence data; presenters should discuss how these might influence future community resource projects in 1-2 slides.

3:15 – 3:45 Jay Shendure (University of Washington)

Constant Innovation: What the Future of Sequencing Holds

3:45 – 4:15 Yingrui Li (BGI)

Sequencing and Assembly of Genomes on a Large Scale 

4:15 – 4:45 Jan Korbel (European Molecular Biology Laboratory)

Beyond SNPs II: Analysis of Structural Variation in the 1000 Genomes Project

4:45 – 5:15      Late Afternoon Snack / Poster Viewing
(Blau Lobby)

5:15 – 7:15      Plenary Session III – Insights into Population Genetics From Large Scale Sequencing

Presenters will discuss major insights into human population genetics, and how the next round of large scale sequencing studies may enable further insights in at least 1-2 slides.

5:15 – 5:45 Gil McVean (University of Oxford)

The Population Genetics of Rare Variation in the 1000 Genomes Project

5:45 – 6:15 John Novembre (University of California Los Angeles)

Insights into Human Demography from Analysis of Coding Sequences in 14,000 Individuals

6:15 – 6:45 Molly Przeworski (University of Chicago)

Beyond the Classic Sweep: Insights into Modes of Adaptation from Genomic Variation Data

            6:45 – 7:00 Michael DeGiorgio (University of California, Berkeley)

Balancing Selection in the Human Genome

            7:00 – 7:15 Alexander Platt (University of California, Los Angeles)

Reconstructing Historical Contributions to Modern Gene Pools

7:15     Dinner on Your Own

Morning of July 13

7:30 – 8:00      Breakfast (Blau Lobby)

Blau Auditorium 

8:00 – 9:45      Plenary Session IV – Studying Human Disease by Genotyping, Imputation and Sequencing

This session will provide examples of contrasting designs for human genetic studies, ranging from case-control studies, to population studies, to studies of founder populations and studies informed by electronic medical records. Presenters are invited to discuss what sort of community resources might be most informative for their ongoing and future genetic studies in at least 1-2 slides. 

8:00 – 8:30 Sekar Kathiresan (Massachusetts General Hospital)

Large Scale Genetic Studies of Cardiovascular Disease

8:30 – 9:00 Augustine Kong (deCode Genetics)

Small is Beautiful: Genetic Studies in the Founder Population of Iceland

9:00 – 9:30 Dan Roden (Vanderbilt University)

Power in Numbers: Connecting Genetics and Medical Practice

            9:30 – 9:45 Andrew Wood (Peninsula Medical School)

1000 Genomes Imputation Identifies Low-Frequency, Large Effect Biomarker Associations


9:45 – 10:15    Morning Break / Poster Viewing (Blau Lobby)

10:15 – 12:00 Plenary Session V – The Evolution of Human Complex Trait Studies

This session will review the evolution of human gene mapping studies for several traits, starting with the era prior to genomewide association studies and ending with examples of current studies informed by 1000 Genomes data and other large scale sequencing efforts. Presenters are invited to discuss what sort of community resources might be most informative for their ongoing and future genetic studies in at least 1-2 slides. 

10:15 – 10:45 Ines Barroso (Wellcome Trust Sanger Institute)

Large Scale Genetic Studies in European Populations

10:45 – 11:15 Michael Boehnke (University of Michigan)

Genetics of Type 2 Diabetes in Diverse Populations

11:15 – 11:45 Judy Cho (Yale University)

Genomic Windows to The Biology of Crohns Disease

11:45 – 12:00 Carlo Sidore (University of Michigan)

Whole Genome Sequencing of 2000 individuals in an Isolated Population

Afternoon of July 13

12:00 – 1:00    Lunch (Colloquium, 6th floor Ross) / Poster Viewing (Blau Lobby)

1:00 – 2:45      Plenary Session VI – The Future is Now: Large Scale Sequencing in Human Disease

This session will review highlights from some of the most informative large scale sequencing studies, with discussion of directions for future studies and how they might be informed (and inform) the design of community resource projects.

1:00 – 1:30 Debbie Nickerson (University of Washington)

Learning about Human Disease Through Exome Sequencing: Examples and Challenges

1:30 – 2:00 Shaun Purcell (Mount Sinai School of Medicine)

Genetics to Study Human Psychiatric Traits

2:00 – 2:30 Cisca Wijmenga (University of Groningen)

The Genome of the Netherlands

            2:30 – 2:45 Jeroen Van Rooij (Erasmus Medical Center)

Exome Sequencing in the Rotterdam Study

2:45 – 3:45      Poster Session
(Blau Lobby)

3:45 – 5:45      Plenary Session VII – The Future of Large Scale Sequencing Studies

This session will discuss ideas for the future of community resource sequencing studies, designed to inform human genetics. Presenters can discuss their own ongoing gene mapping studies but are invited to spend a substantial fraction of their time discussing possibilities for the future, informed by discussions in earlier sessions. 

3:45 – 4:15 Richard Durbin (Wellcome Trust Sanger Institute)

Advances in Genome Assembly and Analysis: What Is Needed?

4:15 – 4:45 Gonçalo Abecasis (University of Michigan)

Advances in Medical Genetics: What Is Needed?

4:45 – 5:15 Andrew Clark (Cornell University)

Maximizing Insights into Human Evolution and Biology

5:15 – 5:45 Nancy Cox (University of Chicago)

Designing Experiments that Help Connect Sequence to Function

5:45 – 6:15      Closing Discussion

An archive of meeting tweets is available here: